Lesson 2

Reversible cell injury. Intracellular accumulation

Key points:

1. Cell injury. Reversible and irreversible, lethal and sublethal injury. Mechanisms and types of cell injury.

2. Morphogenetic mechanisms of intracellular accumulations; their features.

3. Classification of accumulations depending on localization, type of metabolism, prevalence and origin of the process. Concept of thesaurizmoses (diseases of accumulation).

4. Parenchymal dysproteinoses: morphological features, types.

5. Cellular swelling (hydropic dystrophy): commonly affected organs and tissues, causes, morphological characteristics, consequences.

6. Intracellular hyaline accumulation: the most frequent localization, causes, morphological characteristics.

7. Hyperkeratosis (“horny” dystrophy). Causes, localization, morphological manifestations, consequences.

8. Fatty degeneration: localization, morphological characteristics, histological methods of lipid detection.

9. Fatty changes of hepatocytes (liver steatosis): main causes and mechanisms of development, gross and microscopic changes in the organ, results.

10.Fatty degeneration of cardiomyocytes: main causes and mechanisms of development, gross and microscopic changes, consequences.

11.Lipidosis of the renal tubules: the main causes and mechanisms of development, gross and microscopic changes.

12.Hereditary accumulation diseases associated with impaired metabolism of amino acids, lipids and carbohydrates (glycogen).


1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015. P.7-64

2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. Robbins Basic Pathology. 10th ed. Philadelphia, PA: Elsevier/Saunders, 2018. P.1-33, 51

3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: Elsevier Saunders, 2015.

4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edition. Philadelphia, PA: Elsevier Saunders, 2015. P.3-17

5. Harsh Mohan. Essential Pathology for Dental Students.Fourth edition. Jaypee Brothers,Medical Publishers Pvt. Limited, 2011. P.1-77