Lesson 24

Viral Infections

Key points:

1. Viral infections (respiratory viruses: COVID-19, influenza, measles, rubella, chickenpox, mumps, polio, mononucleosis): clinical and morphological manifestations.

2. Rickettsioses: spotted fever, epidemic typhus. Classification, pathomorphology.

3. Acquired immunodeficiency syndrome (AIDS): morphogenesis, clinical and morphological characteristics. AIDS-associated diseases: opportunistic infections, tumors. Complications, causes of death. Pathomorphological changes in HIV infection

4. Rabies: morphological characteristics, causes of death.

5. Latent viral neuroinfections and prion diseases (Kuru, Creutzfeldt-Jakob disease, prion diseases in animals): morphological characteristics.

6. General characteristics of the infectious process: entry port of infection, primary infectious complex, spread and dissemination, ways of transmission of infectious diseases. Morphological variants of local and general reactions at infections: with participation of neutrophils (purulent inflammation); involving lymphocytes and macrophages (mononuclear infiltration and granulomatous inflammation); viral infection response (cytopathic) with the advantage of necrotic local reaction.