Lesson 4

Pigment and Mineral Accumulation

Key points:

1. Disorders of iron metabolism and metabolism of hemoglobinogenic pigments. Classification of hemoglobinogenic pigments. Toxic forms of ferritin: causes and consequences of their formation.

2. Disruption of melanin formation. Morphological characteristics of hypopigmentation (leukoderma, vitiligo, albinism) and hyperpigmentation (general melanoderma, local melanosis, pigment nevus).

3. Disorders of nucleoprotein metabolism. Gout and gouty arthritis: morphological characteristics of joint changes, complications, consequences. Gouty nephropathy: a morphological characteristic.

4. Stone formation: localization, types of stones, consequences and complications of stone formation.


1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015. P.7-64

2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. Robbins Basic Pathology. 10th ed. Philadelphia, PA: Elsevier/Saunders, 2018. P.1-33, 51

3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: Elsevier Saunders, 2015.

4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edition. Philadelphia, PA: Elsevier Saunders, 2015. P.3-17

5. Harsh Mohan. Essential Pathology for Dental Students.Fourth edition. Jaypee Brothers,Medical Publishers Pvt. Limited, 2011. P.1-77

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